Soft sore or soft chancre produces a painful ulcer on the genitals.

The pain tenderness and soft feel of chancroid distinguish it from the painless hard chancre of primary syphilis. It responds well to tetracyclines and also the sulphonamides.

Granuloma inguinale or Donovanosis is rarely seen in temperate countries. It is endemic among the Aboriginals of central and northern Australia and is common around Port Moresby in Papua New Guinea. It has an incubation period of one to four weeks. It causes painless blisters or small papules on the skin of the genitals or thighs which then become raised and irregular and may break down and ulcerate. These lesions heal slowly and may leave marked scarring. Penicillin is not effective but the condition responds to the tetracyclines.

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